On September 9, 1988, the regions of Auvergne-Rhône-Alpes (France), Baden-Wurttemberg (Germany), Catalonia (Spain) and Lombardy (Italy) signed a cooperation agreement constituting the network of the “Four Motors for Europe”. The goals of collaboration in 1988 were primarily related to economics and research as well as to art and culture. In the course of the following decades the scope and intensity of cooperation grew notably.